Cancer drug target discovery in protein-protein interaction networks
نویسنده
چکیده
1. Background Protein-protein interaction networks Proteins are linear chain biomolecules that are the basis of functional networks in all organisms. They include classes that regulate other proteins (e.g. kinases), classes that regulate gene expression (e.g. transcription factors), and classes that control response to disease (e.g. immunoglobulins). Aspects of their social networks have been extensively studied across organisms, particularly in yeast [1]–[3], and humans [4]–[7].
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